Investigating the Synthesis of Nanocatalyst Fe3O4@Arginine-Pd(0) and its Application in the Synthesis of Sulfonamide Derivatives with Antimicrobial Properties

Document Type : Original Research

Authors

1 Department of Plant Physiology and Systems Biology, Iran University.

2 Department of Chemistry, Organic Chemistry, Payam Noor University of Esfahan.

Abstract

Sulfonamide drugs were the first effective antibacterials that were used systemically and paved the way for the antibiotic revolution in medicine. Sulfonamide is a functional group that is the basis of several groups of drugs. The main antibacterial sulfonamides are synthetic (non-antibiotic) antimicrobial agents that contain the sulfonamide group. Some sulfonamides also lack antimicrobial activity. In this project, sulfonamides were synthesized from the reaction of bromoaryl and aniline derivatives in the presence of catalyst Fe3O4@Arginine-Pd(0) in the green solvent of n-hexane at a temperature of 60 oC. The orientation of this catalyst was obtained by FT-IR and TGA analysis, which confirms the successful synthesis of this catalyst. This catalyst has the ability to be regenerated and it works for at least 8 consecutive cycles without reducing the catalytic activity.

Graphical Abstract

Investigating the Synthesis of Nanocatalyst Fe3O4@Arginine-Pd(0) and its Application in the Synthesis of Sulfonamide Derivatives with Antimicrobial Properties

Keywords