Magnetic Heterogeneous Catalyst Ni0.25Mn0.25Cu0.5Fe2O4: Its Efficiency in the Synthesis of Tetrazole Heterocycles with Biological Properties

Document Type : Original Research

Authors

1 Department of Life Sciences and Systems Biology, Plant Physiology Unit, University of Shiraz.

2 Department of Biological, Chemical and Pharmaceutical Sciences, Shiraz Azad University

Abstract

Tetrazoles are an important group of nitrogen-rich heterocycles. These compounds have wide applications in energetic materials, pharmaceutical industries, disease treatment, biochemistry, agriculture, biological imaging and photography. In this article, first the Ni0.25Mn0.25Cu0.5Fe2O4 catalyst was synthesized by conventional hydrothermal method and then identified by inductively coupled plasma analysis, TGA and VSM. Also, this catalyst has magnetic property. The activity of heterogeneous magnetic catalyst Ni0.25Mn0.25Cu0.5Fe2O4 for the synthesis of a wide range of H1-tetrazole derivatives from the ring addition reaction [2-3] of nitrile derivatives and sodium azide in DMSO solvent and at 100 oC was checked. The main advantages of this method are high yield, simple method, easy product separation and catalyst recovery. This catalyst can be easily separated from the reaction mixture by using an external magnet and used for five cycles without significant reduction in catalytic activity.

Graphical Abstract

Magnetic Heterogeneous Catalyst Ni0.25Mn0.25Cu0.5Fe2O4: Its Efficiency in the Synthesis of Tetrazole Heterocycles with Biological Properties

Keywords