Investigating the Synthesis of (3-para-tolyl-isoxazol-5-yl)‌methanol Derivatives Through Oximes

Document Type : Original Research


Department of Life Sciences and Systems Biology, Plant Physiology Unit, University of Turin.


The biological activities of isoxazole compounds are broad and cover a wide range of targets. In recent years, heterocycle compounds have become increasingly popular. An isoxazole ring can enhance the physical and chemical properties of a compound. Compounds designed with isoxazole rings are popular due to their unique properties. In this article, isoxazole compounds have been discussed concerning their use in treating cancer, infection, inflammation, anticancer, and antimicrobial diseases. In the current research work, several compounds have been synthesized. At first, benzaldehyde was converted to benzaldoxime in the form of viscous liquid by hydroxylamine hydrochloride in the presence of base and pyridine solvent. Then, simultaneously with the cyclization process [3+2], (3-para-tolyl-isoxazol-5-yl) methanol was separated in solid form. The structure of the synthesized compounds has been confirmed by FT-IR and 1HNMR spectroscopy.

Graphical Abstract

Investigating the Synthesis of (3-para-tolyl-isoxazol-5-yl)‌methanol Derivatives Through Oximes