Investigation of New Conditions for the Synthesis of Biological Coumarins

Document Type : Original Research

Authors

1 Department of Plant Physiology and Systems Biology, Delhi University.

2 Department of Chemical Sciences and Technologies, Delhi University

Abstract

Due to the growing concern in chemicals and their impact on the environment, a cleaner reaction is required to be included in the chemical chemistry methods. The synthesis of coumarins and their derivatives has attracted a lot of attention from organic and medicinal chemists for many years, because a large number of natural products contain these heterocyclics. In this research, using HCl, Pechmann condensation reaction of coumarin derivatives in water solvent has been reported. HCl is a cheap and readily available acid. This new method has the advantage of being cost-effective, without by-products, high yield of desired products, and without toxic waste and being green.

Graphical Abstract

Investigation of New Conditions for the Synthesis of Biological Coumarins

Keywords