Investigation and Biological Application of MNPs-phenanthroline-Cu as an Efficient Catalyst in the Synthesis of Oxazoles

Document Type : Original Research

Author

Department of Plant Physiology and Systems Biology, University of Esfahan

Abstract

In order to synthesize oxazole derivatives, a convenient, cheap and effective approach has been developed. A moderate to excellent yield of oxazoles is generally obtained from Cu-mediated cyclization/coupling reactions. Oxazole derivatives with functionalized groups may be useful in biological chemistry and medicine. At the para position of the aryl ring, the formation of the oxazole ring may favor the formation of the single bond. And MNPs-phenanthroline-Cu plays a dual role as a Lewis acid catalyst and a C nucleophile in this transformation. A series of spectroscopic techniques were used to characterize the MNPs-phenanthroline-Cu nanocatalyst, including FT-IR, TGA, and ICP-OES. A benzoxazole-generating catalyst was fabricated from MNPs-phenanthroline-Cu nanocomposites. An advantage of the catalyst is its high efficiency and ability to be recovered and reused up to seven times in a row.

Graphical Abstract

Investigation and Biological Application of MNPs-phenanthroline-Cu as an Efficient Catalyst in the Synthesis of Oxazoles

Keywords