Co3O4 Nanocatalyst: A Useful Heterogeneous Catalyst for the Synthesis of Chloroquine in the Treatment of Malaria

Document Type : Original Research

Authors

1 State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, P.R. China.

2 Center for Food Safety and Applied Nutrition, Food and Drug Administration, Nanjing 210096, P.R. China

Abstract

Considering the biological importance and medicinal uses of quinolines as well as their limitations in synthesis methods, an effective method for the synthesis of quinolines has been presented. In this research, we describe a new approach for the synthesis of chloroquine. Chloroquine is mainly used to prevent and treat malaria. It was done by combining raw materials and Co3O4 catalyst at room temperature and during 6 hours and also in PEG solvent. Co3O4 nanoparticles are available and cheap as a catalyst. A good synthesis of chloroquine with good efficiency at room temperature was achieved by combining 4,7-dichloroquinoline and N1,N1-diethylpentane-1,4-diamine in the presence of Co3O4 nanoparticles. It was easy to separate the solid product after adding ethanol to the reaction mixture after separating the catalysts.

Graphical Abstract

Co3O4 Nanocatalyst: A Useful Heterogeneous Catalyst for the Synthesis of Chloroquine in the Treatment of Malaria

Keywords